January 25, 2021 2 min read

Now is the time to learn how Project CBD works with your body's endocannabinoid system. CBD stands for Cannabidiol, and it is a non-intoxicating component of the cannabis plant. It generates significant interest among scientists and physicians during recent years. It shows how the CBD projectexerts its therapeutic impact on a specific molecular level. Cannabidiol majorly considers as a pleiotropic drug that mainly produces many effects through multiple molecular pathways. It also regards scientific literature that identifies more than 65 molecular targets of CBD.

Below are the few factors that show how the CBD project confers its manifold therapeutic effects

Effective Serotonin Receptors

One of the few talented researchers like Jose Alexandre Crippa has now conducted pioneering research into CBD and the neural correlates of anxiety. At one point of high concentrations, CBD automatically activates the 5-HT1A (hydroxytryptamine) serotonin receptor. Therefore, conferring an anti-anxiety effect. This exclusive G-coupled protein receptor has now implicated a variety of biological and neurological processes. It also includes anxiety, addiction, appetite, sleep, pain perception, nausea, and vomiting.

Vanilloid Receptors

CBD tends to interact correctly with different ion channels to confer a therapeutic effect. For example, CBD binds to TRPV1 receptors smartly and functions as ion channels. TRPV1 is also known to mediate pain perception, inflammation, and body temperature. CBD then binds to TRPV1 to influence pain perception. Capsaicin is an aromatic compound that is a part of the hot chili peppers to activate the TRPV1 receptor. Moreover, Anandamide, an endogenous cannabinoid, is also considered as a TRPV1 agonist.

GPR55, Orphan Receptors

Cannabidiol straightforwardly activates the 5-HT1A serotonin receptor and different TRPV ion channels. It also analyzes or indicates that CBD functions as an antagonist restricting or finishing other G protein-coupled receptors known as GRP55. It is also known as an orphan receptor.

PARS, Nuclear Receptors

Project CBD is also known as an anti-cancer effect through effective activation of PPARs that suit the cell's nucleus's surface. It also activates the receptor known as PPAR-gamma as an anti-proliferative effect and induces tumor regression in human lung cancer cell lines. PPAR receptors mainly regulate genes involved in energy homeostasis, lipid uptake, insulin sensitivity, and other metabolic functions.

CBD as a Reuptake Inhibitor

When CBD enters the body, it passes through the cell membrane by hitching a ride with a fatty acid that binds protein (FABP). It also escorts different lipid molecules into the cell's interior. These intracellular transport molecules also escort tetrahydrocannabinol (THC) along with the brain's marijuana-like molecules.

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